Yi-Jan Huang et al. Phys. Rev. A 97 , 032516 (2018)
The ground-state physics of strongly interacting bosonic particles on a hexagonal two-leg ladder geometry is studied with a single-component Haldane model, where an unconventional vortex-lattice phase is found to emerge even for hard-core interactions.
S. Greschner and F. Heidrich-Meisner
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A recipe to construct bound entangled states, i.e., entangled in a way that cannot be distilled, is presented. Contrary to known previous examples, the proposed method leads to states with a simpler structure, considered as generalizations of the well-known states, which may, therefore, be more attractive for experimental investigations.
Enrico Sindici and Marco Piani
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The use of optical nonlinearities to implement quantum logical gates at the single-photon level is analytically investigated. A thorough discussion on why previous no-go arguments may not hold is presented.
Balakrishnan Viswanathan and Julio Gea-Banacloche Phys. Rev. A 97 , 032314 (2018)
Vol. 97, Iss. 4 — April 2018
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Together with the conference organizers, the editors of the Physical Review Journals are pleased to announce a special symposium of invited talks at Metamaterials 2018 , highlighting some of the latest works within and beyond the traditional domain of metamaterials research.
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Technology. People. Imagination.
If you are designing or building REST APIs, you should be aware of two very important properties of HTTP methods: idempotency and safety . These properties are defined in the HTTP specification . I’m calling them properties, but ‘ guarantees’ would be a better term: you don’t automatically get them; you actually need to design for these guarantees because your clients expect you to follow the contract. Let’s get the definitions out of the way first and then we’ll look at the contract and why it’s important to stick to it.idempotency and safety guarantees’
An operation is idempotent if it will produce the same results when executed once or multiple times . For example, it doesn’t matter how many times I submit a request to set my current location to ‘San Francisco’. The final outcome will be the same: the city field in the database is set to ‘San Francisco’. On the other hand, a request to POST a new message to the forum is not idempotent : the same message will be stored or sent multiple times if the client. Some people, wrongly, assume that for a request to be idempotent, the same response must be sent back to the client each time: idempotency has nothing to do with the response that’s sent back to the client. It’s a server side guarantee ensuring that the state of the resource on the server does not change any further after the first request, no matter how many times the request is duplicated.idempotent if it will produce the same results when executed once or multiple times state of the resource on the server
Some idempotent operations have an additional,
: they do not modify the state on the server side at all. Simply put, these methods are read-only and have absolutely zero side-effects. For example, a query to retrieve my current city doesn’t change the database. These types of operations are given a
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Related is the idea of nullipotence: a function is nullipotent if not calling it at all has the same side effects as calling it once or more . In practice, this simply means that the function doesn’t have any side effects at all. A database query saying “get row 42” is a good example. Nullipotence is clearly a stronger condition than idempotence.
Aberrant energy metabolism represents a hallmark of cancer and contributes to numerous aggressive behaviors of cancer cells, including cell death and survival. Despite the poor prognosis of mantle cell lymphoma (MCL), due to the inevitable development of drug resistance, metabolic reprograming of MCL cells remains an unexplored area. Posttranslational modification of proteins via O- GlcNAcylation is an ideal sensor for nutritional changes mediated by O -GlcNAc transferase (OGT) and is removed by O -GlcNAcase (OGA). Using various small-molecule inhibitors of OGT and OGA, we found for the first time that O- GlcNAcylation potentiates MCL response to bortezomib. CRISPR interference of MGEA5 (encoding OGA) validated the apoptosis sensitization by O- GlcNAcylation and OGA inhibition. To identify the potential clinical candidates, we tested MCL response to drug-like OGA inhibitor, ketoconazole, and verified that it exerts similar sensitizing effect on bortezomib-induced apoptosis. Investigations into the underlying molecular mechanisms reveal that bortezomib and ketoconazole act in concert to cause the accumulation of truncated Bid (tBid). Not only does ketoconazole potentiate tBid induction, but also increases tBid stability through O- GlcNAcylation that interferes with tBid ubiquitination and proteasomal degradation. Remarkably, ketoconazole strongly enhances bortezomib-induced apoptosis in de novo bortezomib-resistant MCL cells and in patient-derived primary cells with minimal cytotoxic effect on normal peripheral blood mononuclear cells and hepatocytes, suggesting its potential utility as a safe and effective adjuvant for MCL. Together, our findings provide novel evidence that combination of bortezomib and ketoconazole or other OGA inhibitors may present a promising strategy for the treatment of drug-resistant MCL. Mol Cancer Ther; 17(2); 484–96. ©2017 AACR .
Note: Supplementary data for this article are available at Molecular Cancer Therapeutics Online (http://mct.aacrjournals.org/).Note:
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